Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development
نویسندگان
چکیده
منابع مشابه
Smad4 and Trim33/Tif1γ redundantly regulate neural stem cells in the developing cortex.
During central nervous system (CNS) development, proliferation and differentiation of neural stem cells (NSCs) have to be regulated in a spatio-temporal fashion. Here, we report different branches of the transforming growth factor β (TGFβ) signaling pathway to be required for the brain area-specific control of NSCs. In the midbrain, canonical TGFβ signaling via Smad4 regulates the balance betwe...
متن کاملTAK1 is activated by TGF-β signaling and controls axonal growth during brain development.
Dear Editor, Mammalian central nervous system neurons show asymmetry during early brain development that defines the elaborate function of neural circuitry (Kriegstein and Noctor, 2004). Many intracellular signaling pathways, which are important for the transition to the polarized state and the development of axons and dendrites, have been identified (Barnes and Polleux, 2009). How these pathwa...
متن کاملLAT-derived microRNAs in HSV-1 target SMAD3 and SMAD4 in TGF-β/Smad signaling pathway
Background: During its latent infection, HSV-1 produces only a miRNA precursor called LAT, which encodes six distinct miRNAs. Recent studies have suggested that some of these miRNAs could target cellular mRNAs. One of the key cell signaling pathways that can be affected by HSV-1 is the TGF-β/Smad pathway. Herein, we investigated the potential role of the LAT as well as three LAT-derived miRNAs ...
متن کاملSmad4-mediated TGF-β signaling in tumorigenesis
Transforming growth factor-beta (TGF-beta) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the common mediator Smad4. The dual effects of TGF-beta signaling on tumor initiation and progression are cell-specific and yet to be determined under distinct contexts. A number of genetically ma...
متن کاملJab1 antagonizes TGF-β signaling by inducing Smad4 degradation
Tumor suppressor Smad4 is the common signaling effector in the transforming growth factor β (TGF-β) superfamily. Phosphorylated regulatory Smads (R-Smads) interact with Smad4, and the complex translocates into the nucleus to regulate gene transcription. Proper TGF-β signaling requires precise control of Smad functions. Smurfs have been shown to mediate the degradation of R-Smads but not the com...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2015
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2014.12.006